ABSTRACT
Introduction: Miscarriage is the spontaneous loss of theconceptus before 20 weeks of gestation. Several disordersare known to contribute to recurrent miscarriage including:chromosomal anomalies; anti-cardiolipin antibodies;endocrine disorders such as poorly controlled diabetesmellitus; hyperprolactinaemia and thyroid diseases; andpelvic anatomic abnormalities. Study aimed to investigate theendocrine dysfunction in recurrent pregnancy lossMaterial and Methods: A prospective study comprising 70subjects was carried out. Fifty cases of recurrent abortionsconstituted the study group. Twenty healthy multipara femalesof same reproductive age group constituted the controlgroup. Venous blood samples were collected, and serum wasanalyzed for hormone analysis (T3, T4, TSH, LH, FSH, PRL,Testosterone) by ELISA method.Results: The mean prolactin level in cases of recurrentabortions was 19.96 ng/ml, while in controls was 11.77 ng/ml. The p value was 0.006 which was found to be statisticallyhighly significant. The mean TSH level in recurrent abortionscases was 5.81 mIU/L, while in controls was 1.95 mIU/L. Thep value was 0.004 which was found to be statistically highlysignificant.Conclusion: The patients with recurrent abortions hadsignificantly raised levels of TSH and Prolactin. Theprevalence of thyroid disorder and hyperprolactinemiawere higher in pregnant women with a history of recurrentabortion compared with healthy pregnant control population.Universal screening of pregnant females for endocrine profilecan improve the foetal outcome as well as social well-beingof females.
ABSTRACT
Introduction: Time since death is an important topic that playsmajor role in forensic medicine. The accurate determinationof time since death is found to be helpful in medico legalinvestigation. Advancements in the methods for estimatingtime since death have enabled us to determine post-morteminterval more precisely. Since the 1850s, scientists have beenworking on different methods to determine post-morteminterval. Hence, the aim of the present study was to assess thetime since death using method of rigor mortis in the autopsiesdone at the mortuary of Osmania General Hospital.Materials and Methods: About 500 medico-legal autopsieswere selected where the exact time of death was known andthe body had been kept at prevailing room temperature. Agood quality digital hygrometer was used to note the dailyreadings of temperature and humidity. Presence or absence ofrigor mortis and its extent was noticed in both voluntary andinvoluntary muscles.Results: More unnatural deaths are in suspiciouscircumstances are occurring in males when compared tofemales. The average duration for onset of rigor mortis was 8hours and 39 minutes. The minimum duration in which rigormortis had begun to appear in the body was 1 hour and 35minutes while the longest maximum by which rigor mortishad not completely appeared in the body was 24 hours.Conclusion: Rigor mortis has been used for assessment oftime since death from long time. It is considered to be themost important and interesting method to estimate the timesince death.